Magnetoencephalography using gradient magnetic field topography (GMFT) can predict successful anterior corpus callosotomy in patients with drop attacks. Issue 1 (January 2016)

• Record Type: Journal Article
• Authors: Kagawa, Kota; Iida, Koji; Hashizume, Akira; Katagiri, Masaya; Baba, Shiro; Kurisu, Kaoru; Otsubo, Hiroshi
• Is Part Of: Clinical neurophysiology. Volume 127:Issue 1(2016:Jan.)
• Page Start: 221
• Page End: 229
• Publication Date: 2016-01
• Subjects: Drop attack -- Generalized spikes -- Anterior/posterior spikes -- Spreading pattern -- Secondary bilateral synchrony; Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electromyography -- Periodicals; Neurology -- Periodicals; 612.8
• DOI: 10.1016/j.clinph.2015.04.292
• Languages: English
• ISSNs: 1388-2457

Abstract

Highlights: GMFT can reveal distributions and spreading patterns of generalized spikes in patients with drop attacks. Good outcome was correlated with higher proportion of anterior bilateral spikes. The anterior 2/3 corpus callosum might be a part of ictogenic pathway of drop attack. Abstract: Objective: Gradient magnetic field topography (GMFT) with magnetoencephalography (MEG) has been developed to demonstrate magnetic-field gradients of epileptic spikes on a volume-rendered brain surface. We evaluated GMFT in patients with anterior 2/3 corpus callosotomy (ACC) for drop-attacks. Methods: Eight patients (age; 11–37 years) underwent ACC. GMFT evaluated the predominant distributions (anterior/posterior) and the spreading patterns (unilateral/bilateral) of pre- and postoperative interictal MEG spikes corresponding to generalized spikes on EEG. We compared the occurrence of four types of spikes; anterior unilateral spike (AUS), posterior unilateral spike (PUS), anterior bilateral spike (ABS), posterior bilateral spike (PBS) between 5 patients (group G) with good control of drop attacks and 3 patients (group P) with residual drop attacks. Results: Preoperatively, GMFT showed the proportion of ABS in group G (mean ± SD, 57.4 ± 9.7%) was significantly ( p = 0.024) higher than that in group P (31.6 ± 15.2%). The number and proportion of postoperative ABS and PBS in group G were significantly decreased ( p < 0.05 in all). Conclusion: GMFT is valuable to evaluate pre- and post-operative predominant spikes in patients with drop attacks. Significance: GMFT revealed a higher proportion of preoperative ABS and postoperative decline of both ABS and PBS in patients with good control of drop attacks after ACC.