Grading hypoxic–ischemic encephalopathy severity in neonatal EEG using GMM supervectors and the support vector machine. Issue 1 (January 2016)

• Record Type: Journal Article
• Authors: Ahmed, Rehan; Temko, Andriy; Marnane, William; Lightbody, Gordon; Boylan, Geraldine
• Is Part Of: Clinical neurophysiology. Volume 127:Issue 1(2016:Jan.)
• Page Start: 297
• Page End: 309
• Publication Date: 2016-01
• Subjects: Neonatal EEG -- Support vector machine -- Automated neonatal HIE EEG grading system -- Hypoxic–ischemic encephalopathy -- Gaussian mixture models -- EEG -- Long term EEG features -- EEG analysis algorithms; Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electromyography -- Periodicals; Neurology -- Periodicals; 612.8
• DOI: 10.1016/j.clinph.2015.05.024
• Languages: English
• ISSNs: 1388-2457

Abstract

Highlights: An automated system for grading hypoxic–ischemic encephalopathy (HIE) severity using EEG is presented. The classification approach is based on long-term statistical model based features. The proposed system could act as a decision support system to assist health care professionals in NICUs. Abstract: Objective: This work presents a novel automated system to classify the severity of hypoxic–ischemic encephalopathy (HIE) in neonates using EEG. Methods: A cross disciplinary method is applied that uses the sequences of short-term features of EEG to grade an hour long recording. Novel post-processing techniques are proposed based on majority voting and probabilistic methods. The proposed system is validated with one-hour-long EEG recordings from 54 full term neonates. Results: An overall accuracy of 87% is achieved. The developed grading system has improved both the accuracy and the confidence/quality of the produced decision. With a new label 'unknown' assigned to the recordings with lower confidence levels an accuracy of 96% is attained. Conclusion: The statistical long-term model based features extracted from the sequences of short-term features has improved the overall accuracy of grading the HIE injury in neonatal EEG. Significance: The proposed automated HIE grading system can provide significant assistance to healthcare professionals in assessing the severity of HIE. This represents a practical and user friendly implementation which acts as a decision support system in the clinical environment. Its integration with other EEG analysis algorithms may improve neonatal neurocritical care.