In-depth performance analysis of an EEG based neonatal seizure detection algorithm. Issue 5 (May 2016)

• Record Type: Journal Article
• Authors: Mathieson, S.; Rennie, J.; Livingstone, V.; Temko, A.; Low, E.; Pressler, R.M.; Boylan, G.B.
• Is Part Of: Clinical neurophysiology. Volume 127:Issue 5(2016:May)
• Page Start: 2246
• Page End: 2256
• Publication Date: 2016-05
• Subjects: Automated seizure detection -- Neonatal seizures; Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electromyography -- Periodicals; Neurology -- Periodicals; 612.8
• DOI: 10.1016/j.clinph.2016.01.026
• Languages: English
• ISSNs: 1388-2457

Abstract

Highlights: A novel method for in-depth analysis of neonatal seizure detection algorithms is proposed. The analysis estimated how seizure features are exploited by automated detectors. This method led to significant improvement of the ANSeR algorithm. Abstract: Objective: To describe a novel neurophysiology based performance analysis of automated seizure detection algorithms for neonatal EEG to characterize features of detected and non-detected seizures and causes of false detections to identify areas for algorithmic improvement. Methods: EEGs of 20 term neonates were recorded (10 seizure, 10 non-seizure). Seizures were annotated by an expert and characterized using a novel set of 10 criteria. ANSeR seizure detection algorithm (SDA) seizure annotations were compared to the expert to derive detected and non-detected seizures at three SDA sensitivity thresholds. Differences in seizure characteristics between groups were compared using univariate and multivariate analysis. False detections were characterized. Results: The expert detected 421 seizures. The SDA at thresholds 0.4, 0.5, 0.6 detected 60%, 54% and 45% of seizures. At all thresholds, multivariate analyses demonstrated that the odds of detecting seizure increased with 4 criteria: seizure amplitude, duration, rhythmicity and number of EEG channels involved at seizure peak. Major causes of false detections included respiration and sweat artefacts or a highly rhythmic background, often during intermediate sleep. Conclusion: This rigorous analysis allows estimation of how key seizure features are exploited by SDAs. Significance: This study resulted in a beta version of ANSeR with significantly improved performance.