Association between high-sensitive troponin I and coronary artery calcification in a Danish general population. (February 2016)

• Record Type: Journal Article
• Authors: Olson, Fredrik; Engborg, Jonathan; Grønhøj, Mette H.; Sand, Niels P.; Lambrechtsen, Jess; Steffensen, Flemming H.; Nybo, Mads; Gerke, Oke; Mickley, Hans; Diederichsen, Axel C.P.
• Is Part Of: Atherosclerosis. Volume 245(2016)
• Page Start: 88
• Page End: 93
• Publication Date: 2016-02
• Subjects: High-sensitive troponin I -- Coronary artery calcification -- Agatston score -- DanRisk -- Cardiovascular risk -- Coronary artery disease -- General population; Arteriosclerosis -- Periodicals; Electronic journals; 616.136
• DOI: 10.1016/j.atherosclerosis.2015.12.017
• Languages: English
• ISSNs: 0021-9150

Abstract

Abstract: Background: High-sensitive troponin I (hs-TnI) is an individual predictor of future cardiovascular disease (CVD). However, the relationship between hs-TnI and coronary artery calcification (CAC) as determined by computed tomography (CT) has not previously been investigated in a general population. Methods: 1173 randomized, middle-aged subjects without known CVD underwent a non-contrast cardiac-CT scan for CAC determination. Hs-TnI was detected using ARCHITECT STAT High Sensitive Troponin-I immunoassay. Total 10-year cardiovascular mortality risk was estimated using HeartScore. The relationship between hs-TnI and CAC was assessed using logistic regression analyses and receiver operating characteristic curves (ROC). Results: Concentrations of hs-TnI above the limit of detection were measured in 89.3% of all subjects. Presence of CAC (Agatston score >0) was detected in 29% in the lowest hs-TnI quartile compared with 55% in the highest, with a stepwise increase over the quartiles. In fully adjusted regression models with dichotomous CAC outcomes, hs-TnI was able to predict presence of CAC (OR: 1.25, 95% CI: 1.03–1.51, p = 0.025) and an Agatston score >100 (OR: 1.36, 95% CI: 1.08–1.71, p = 0.009). Subjects in the fourth hs-TnI quartile had an increased risk for presence of CAC (OR: 1.56, 95% CI: 1.06–2.26, p = 0.024) and for an Agatston score >100 (OR: 1.82, 95% CI: 1.04–3.18, p = 0.035), when compared with the first quartile. Addition of hs-TnI to HeartScore improved the ROCAUC from 0.671 to 0.695 (p < 0.0001). Conclusion: Hs-TnI was associated with CAC in a Danish middle-aged population without previously known CVD. This is a step towards understanding hs-TnI as a risk marker for CVD. Highlights: Hs-TnI and CAC are powerful predictors of CVD and death. Hs-TnI and CAC was studied in a random selection of 1173 subjects from the general population. There was a significant association between hs-TnI and CAC. This is a step towards understanding hs-TnI as a predictor future CVD.