Vitamin D receptor GATG haplotype association with atherosclerotic disease in patients with rheumatoid arthritis. (February 2016)

• Record Type: Journal Article
• Authors: López-Mejías, Raquel; Genre, Fernanda; Remuzgo-Martínez, Sara; Robledo, Gema; Llorca, Javier; Corrales, Alfonso; González-Juanatey, Carlos; Ubilla, Begoña; Mijares, Verónica; Pina, Trinitario; Blanco, Ricardo; Castañeda, Santos; Martín, Javier; González-Gay, Miguel A.
• Is Part Of: Atherosclerosis. Volume 245(2016)
• Page Start: 139
• Page End: 142
• Publication Date: 2016-02
• Subjects: Atherosclerosis -- Carotid plaques -- Polymorphisms -- Rheumatoid arthritis -- Vitamin D receptor; Arteriosclerosis -- Periodicals; Electronic journals; 616.136
• DOI: 10.1016/j.atherosclerosis.2015.12.011
• Languages: English
• ISSNs: 0021-9150

Abstract

Abstract: Introduction: An association between the vitamin D receptor (V DR ) GAT haplotype and coronary artery disease (CAD) in type-2 diabetes has recently been described. Since cardiovascular mortality in rheumatoid arthritis (RA) is comparable to that observed for patients with type-2 diabetes, we aimed to determine if V DR GAT haplotype is also associated with atherosclerotic disease in RA. Material and Methods: 591 Northern Spanish RA patients were genotyped for 4 VDR polymorphisms (rs731236 A/G; rs7975232 A/C; rs1544410C/T; rs2228570 G/A). Atherosclerotic disease was established by the presence of carotid plaques in carotid ultrasound. Results: VDR rs7975232 AA genotype was increased in RA patients with plaques (p = 0.045, OR = 1.46 [1.01–2.18]). More importantly, the frequency of carotid plaques was significantly increased in RA patients who carried the GATG haplotype (p = 0.009, OR = 1.56 [1.09–2.42]). Conclusion: Our results suggest a potential VDR GATG haplotype association with atherosclerotic disease in RA patients.