Changes in Platelet Count and Size Indices in Adolescent Patients With Anorexia Nervosa. (September 2017)

• Record Type: Journal Article
• Authors: Oświęcimska, Joanna; Malczyk, Żaneta; Szymlak, Agnieszka; Mikołajczak, Agata; Ziora, Katarzyna; Zamlynski, Jacek; Machura, Edyta; Zajac, Piotr; Koczy, Bogdan; Kasperska-Zajac, Alicja
• Is Part Of: Clinical and applied thrombosis/hemostasis. Volume 23:Number 6(2017)
• Page Start: 562
• Page End: 566
• Publication Date: 2017-09
• Subjects: platelet indices -- mean platelet volume -- platelet distribution width -- platelet count -- anorexia nervosa; Hemostasis -- Periodicals; Thrombosis -- Periodicals; 616.13
• DOI: 10.1177/1076029617705727
• Languages: English
• ISSNs: 1076-0296

Abstract

The significance of platelet size indices has not been widely analyzed in anorexia nervosa (AN). It seems important to get more knowledge on the easily available indices of platelet function obtained by routine complete blood count analysis in patients with AN. We analyzed platelet count (PLT), platelet distribution width (PDW), and mean platelet volume using an automated blood cell counter in 25 females with AN and healthy age- and gender-matched nonatopic controls. Mean PLT was significantly lower in patients with AN than in the control group. Platelet distribution width values in patients with AN were significantly higher than those in the controls. Platelet distribution width values significantly correlated with the disease duration and rate of body weight loss in the anorectic patients. Anorexia nervosa in adolescents is associated with a decrease in PLT along with an increased PDW, which may be an indicator of dysregulated thrombopoiesis.