Two new compounds with antimicrobial activities from the seeds of Voacanga africana. (December 2016)

• Record Type: Journal Article
• Authors: Niu, Yifeng; Yang, Chen; Zhou, Jing; Huang, Shen; Liu, Jiajia
• Is Part Of: Phytochemistry letters. Volume 18(2016:Dec.)
• Page Start: 208
• Page End: 212
• Publication Date: 2016-12
• Subjects: Thiophene compounds -- Voacanga -- Antibiotic; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2016.10.019
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: Two new compounds were isolated from the seeds of Voacanga africana. . Their structures were determined on the basis of extensive spectroscopic analyses. Both compounds displayedhigh antibacterial activities. Abstract: Two new compounds, ( R )-4-(2-methylpentyl)-4 H -dithieno[2, 3- b :3′, 2′- e ]pyran (1 ) and 4-(2-ethylbutyl)-4 H -dithieno[2, 3 -b :3′, 2′ -e ]pyran (2 ) were extracted from the seeds of Voacanga africana . The molecular structures of these compounds were measured with the help of broad spectroscopic (1D and2D-NMR, IR, ESI-TOF-MS, HR-MS ) analyses. The primary pharmacological operations of these compounds were brought to evaluation by applying the antibacterial extrasomatic test. The results revealed that compound1 and2 were in an effective position to stop the growth of Escherichia coli, Streptococcus and Salmonella typhi . On the other hand, the inhibitory impacts on Staphylococcus aureus as well as Pseudomonas aeruginosa were not apparent.