Spermatogonial cells: mouse, monkey and man comparison. (November 2016)

• Record Type: Journal Article
• Authors: Boitani, Carla; Di Persio, Sara; Esposito, Valentina; Vicini, Elena
• Is Part Of: Seminars in cell & developmental biology. Volume 59(2016)
• Page Start: 79
• Page End: 88
• Publication Date: 2016-11
• Subjects: ID4 inhibitor of DNA binding 4 -- GPR125 G protein-coupled receptor 125 -- STRA8 stimulated by retinoic acid 8 -- FGFR3 fibroblast growth factor receptor 3 -- MAGE-A4 melanoma antigen family A4 -- SSEA4 stage-specific embryonic antigen-4 -- UTF1 undifferentiated embryonic cell transcription factor 1 -- POU5F1 POU domain, class 5, transcription factor 1 -- ZBTB16 zinc finger and BTB domain containing 16 -- SALL4 spalt-like transcription factor 4 -- CDH1 cadherin 1, type 1 -- UCHL1 ubiquitin carboxyl-terminal hydrolase isozyme L1 -- Thy-1 thymocyte cell surface antigen -- GFRA1 GDNF family receptor alpha 1 -- NGN3 neurogenin 3 -- PAX7 paired box 7; Spermatogonia -- Spermatogonial stem cells -- Spermatogonial stem cell niche -- Non-human primates -- Mouse -- Human; Cytology -- Periodicals; Developmental biology -- Periodicals; 571.6
• DOI: 10.1016/j.semcdb.2016.03.002
• Languages: English
• ISSNs: 1084-9521

Abstract

Highlights: Most knowledge on mammalian spermatogonia derives from mouse models. Limited information on spermatogonia is available for human and non-human primates. The spermatogonial compartment is phenotipically and functionally heterogeneous. Extrinsic factors regulate spermatogonia self-renewal and differentiation in a cyclic manner. Abstract: In all mammals, spermatogonia are defined as constituting the mitotic compartment of spermatogenesis including stem, undifferentiated and differentiating cell types, possessing distinct morphological and molecular characteristics. Even though the real nature of the spermatogonial stem cell and its regulation is still debated the general consensus holds that in steady-state spermatogenesis the stem cell compartment needs to balance differentiation versus self-renewal. This review highlights current understanding of spermatogonial biology, the kinetics of amplification and the signals directing spermatogonial differentiation in mammals. The focus will be on relevant similarities and differences between rodents and non human and human primates.