Cytotoxic 9, 19-cycloartane triterpenoids from the roots of Cimicifuga foetida L. (December 2016)

• Record Type: Journal Article
• Authors: Zhu, Guo-Lei; Nian, Yin; Zhu, Di-Fan; Wan, Luo-Sheng; Bao, Ni-Man; Wang, Wei-Hua; Zhou, Lin; Qiu, Ming-Hua
• Is Part Of: Phytochemistry letters. Volume 18(2016:Dec.)
• Page Start: 105
• Page End: 112
• Publication Date: 2016-12
• Subjects: Cimicifuga foetida L. -- 9, 19-Cycloartane triterpenoids -- Cytotoxicity; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2016.06.002
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: Eight new 9, 19-cycloartane triterpenoids (1 –8 ) were isolated from the roots of Cimicifuga foetida L. The structures of the isolated new compounds were clearly elucidated by extensive MS, 1D, 2D NMR spectroscopic technologies. Compound 2 showed significant cytotoxic activity against five cancer cell lines with IC50 value from 2.61 to 3.32 μM. Abstract: Eight new cycloartane triterpenoids (1 –8 ), along with eight known analogues (9 –16 ), were isolated from the roots of Cimicifuga foetida L. Their structures were elucidated by spectroscopic analysis and acidic hydrolysis. All of the new compounds were evaluated for their in vitro cytotoxicity against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7 and SW480), and compound2 showed inhibitory activities with IC50 values raging from 2.61 to 3.32 μM.