Saniculamins A and B, two new flavonoids from Sanicula lamelligera Hance inhibiting LPS-induced nitric oxide release. (December 2016)

• Record Type: Journal Article
• Authors: Xu, Guangming; Wang, Zheming; Zhao, Biqing; Liu, Nianzheng; Yang, Shenghui; Liu, Yonghong; Wang, Junfeng; Zhou, Xiaojiang
• Is Part Of: Phytochemistry letters. Volume 18(2016:Dec.)
• Page Start: 35
• Page End: 38
• Publication Date: 2016-12
• Subjects: Sanicula lamelligera -- Flavonoid -- Anti-inflammatory activity -- Nitric oxide release; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2016.08.022
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Compounds1–3 exhibited the inhibitory effects on LPS-induced nitric oxide production with IC50 values of 2.31, 4.48 and 16.52 μM, respectively. Highlights: Two new flavonoids were isolated from the whole plants of Sanicula lamelligera Hance. Their structures were established by the analysis of spectroscopic data. Compounds1 and2 inhibited the NO release with IC50 values of 2.31 and 4.48 μM. Abstract: Two new flavonoids, saniculamins A and B (1 and2 ), together with three known flavonoid derivatives brosimacutin (3 ), 6-flavonol (4 ), and eucomol (5 ) were isolated from the whole plants of Sanicula lamelligera Hance collected in Mountain Emei, Sichuan Province, People's Republic of China. The structures of all isolated compounds were determined on the basis of extensive spectroscopic analyses, including 1D/2D NMR, and HRMS data, as well as by comparison with literature reports. Compounds1–3 exhibited the inhibitory effects on LPS-induced nitric oxide production with IC50 values of 2.31, 4.48 and 16.52 μM, respectively.