Effect of l-serine and l-threonine on volumetric and acoustic behaviour of aqueous metformin hydrochloride solutions at T = (305.15, 310.15 and 315.15) K. (April 2016)

• Record Type: Journal Article
• Authors: Kumar, Harsh; Behal, Isha; Singla, Meenu
• Is Part Of: Journal of chemical thermodynamics. Volume 95(2016:Apr.)
• Page Start: 1
• Page End: 14
• Publication Date: 2016-04
• Subjects: Amino acid -- Apparent molar volume -- Apparent molar isentropic compression -- Metformin hydrochloride -- (Ion + ion) interaction; Thermodynamics -- Periodicals; Thermochemistry -- Periodicals; Thermodynamique -- Périodiques; Thermochimie -- Périodiques; Thermochemistry; Thermodynamics; Periodicals; 541.369
• DOI: 10.1016/j.jct.2015.11.020
• Languages: English
• ISSNs: 0021-9614

Abstract

Highlights: Densities and speeds of sound of amino acids in aqueous metformin hydrochloride. Transfer volume decrease with the increase in size of alkyl side chain of amino acids. (Ion + hydrophilic) and (hydrophilic + hydrophilic) interactions are present. Pair-wise interactions are dominant in the mixtures. Abstract: The interactions ofl -serine andl -threonine with drug metformin hydrochloride (Metformin-HCl) as a function of temperature have been investigated by combination of volumetric and acoustic methods. Densities and speeds of sound ofl -serine andl -threonine in (0.00, 0.03, 0.045, 0.06 and 0.09) mol · kg −1 aqueous solutions of Metformin-HCl have been measured at T = (305.15, 310.15 and 315.15) K and experimental pressure p = 0.1 MPa. The apparent molar volume V ϕ, the partial molar volume V ϕ ° and standard partial molar volumes of transfer Δ V ϕ ° forl -serine andl -threonine from water to aqueous Metformin-HCl solutions have been calculated from density data. Partial molar isentropic compression K ϕ, s and partial molar isentropic compression of transfer Δ K ϕ, s ° have been calculated from speed of sound data. The pair and triplet interaction coefficient have also been calculated. The results have been explained based on competing patterns of interactions of co-solvents and the solute.