Impact of comorbidity index on morbidity and survival in non-small cell lung cancer. (January 2016)

• Record Type: Journal Article
• Authors: Otake, Sotaro; Ohtsuka, Takashi; Asakura, Keisuke; Kamiyama, Ikuo; Kohno, Mitsutomo
• Is Part Of: Asian cardiovascular & thoracic annals. Volume 24:Number 1(2016)
• Page Start: 30
• Page End: 33
• Publication Date: 2016-01
• Subjects: Carcinoma -- non-small cell lung cancer -- Comorbidity -- Health status indicators -- Lung neoplasms -- Survival analysis; Heart -- Diseases -- Asia -- Periodicals; Heart -- Diseases -- Pacific Area -- Periodicals; Heart -- Diseases -- Periodicals; Heart -- Surgery -- Asia -- Periodicals; Heart -- Surgery -- Pacific Area -- Periodicals; Heart -- Surgery -- Periodicals; Chest -- Surgery -- Asia -- Periodicals; Chest -- Surgery -- Pacific Area -- Periodicals; Chest -- Surgery -- Periodicals; 617.412
• DOI: 10.1177/0218492315617834
• Languages: English
• ISSNs: 0218-4923

Abstract

Background: The number of surgeries in older patients with comorbidities is constantly growing. The present study examined the impact of comorbidity on postoperative complications and long-term survival in patients with completely resected non-small cell cancer. Methods: Between 2004 and 2008, 423 patients with non-small cell lung cancer underwent complete resection. A retrospective comparison of perioperative mortality, morbidity, Charlson comorbidity index (CCI), and postoperative length of hospital stay was performed. Results: The number of patients with CCI 0, 1–2, and ≥3 was 226, 170 and 27, respectively. The 5-year overall survival was 88% among patients with CCI 0, and 84% in those with CCI ≥1 ( p = 0.05) in all pathological stages. The CCI 0 group had significantly better overall survival than CCI 0 group and 30 (15%) in the CCI ≥1 group ( p = 0.024). Length of stay was shorter in the CCI 0 group (11 ± 5 days) than in the CCI ≥1 group (15 ± 19 days, p = 0.015). Conclusions: A high CCI correlated with higher postoperative morbidity and longer length of stay. We identified better a prognosis in patients with CCI 0 compared to those with CCI 1–2.