Mono- and binuclear copper(II) complexes of the bipyridine ligand: Structural, electrochemical and biological studies. (25th September 2015)

• Record Type: Journal Article
• Authors: Jayamani, Arumugam; Sengottuvelan, Nallathambi; Kang, Sung Kwon; Kim, Young-Inn
• Is Part Of: Polyhedron. Volume 98(2015)
• Page Start: 203
• Page End: 216
• Publication Date: 2015-09-25
• Subjects: Bipyridine -- Hirshfeld surface -- Binding affinity -- Cleavage studies -- Antimicrobial activity; Chemistry, Inorganic -- Periodicals; Chimie inorganique -- Périodiques; Organometaalverbindingen; Anorganische chemie; 546.05
• DOI: 10.1016/j.poly.2015.05.042
• Languages: English
• ISSNs: 0277-5387

Abstract

Graphical abstract: Single crystals of five copper(II) complexes have been synthesized and characterized. The molecular Hirshfeld surfaces and fingerprint plots of the complexes were investigated. The complexes have efficient DNA and protein binding properties, showing oxidative cleavage by a singlet oxygen mechanism and better antimicrobial activity. Abstract: The copper(II) complexes [Cu(bpy)2 (ClO4 )](ClO4 ) (1 ), [Cu(bpy)2 (Cl)](ClO4 ) (2 ), [Cu(bpy)2 (CH3 COO)](ClO4 ) (3 ), [Cu2 (bpy)2 (μ-OH)2 (μ-ClO4 )2 ] (4 ) and [Cu2 (bpy)2 (μ-OH)(μ-H2 O)(μ-CH3 COO)](ClO4 )2 (5 ) (where bpy = 2, 2′-bipyridine) have been synthesized and characterized by single crystal analysis, elemental analysis and spectroscopic methods. Complexes2 and4 crystallize in the monoclinic P 21 / n and C 2/ m space groups respectively, and the other complexes crystallize in the triclinic P 1 ¯ space group. The molecular Hirshfeld surfaces and fingerprint plots of the complexes were investigated. Complexes1 –3 exhibit one quasi-reversible and complexes4 and5 exhibit two quasi-reversible redox cyclic voltammetric responses near the cathodic region in DMF. Binding studies of the complexes with BSA and ctDNA showed good binding affinity. Cleavage of pBR322 DNA by the complexes shows efficient oxidative cleavage in the presence of MPA through the formation of singlet oxygen. The complexes were also screened for their antimicrobial activities, which indicated that the complexes exhibit a zone of inhibition like that of standard drugs.