Lipoprotein-associated phospholipase A2 and risk of incident peripheral arterial disease in a multi-ethnic cohort: The Multi-Ethnic Study of Atherosclerosis. (February 2017)

• Record Type: Journal Article
• Authors: Garg, Parveen K; Jorgensen, Neal W; McClelland, Robyn L; Jenny, Nancy S; Criqui, Michael H; Allison, Matthew A; Greenland, Philip; Rosenson, Robert S; Siscovick, David S; Cushman, Mary
• Is Part Of: Vascular medicine. Volume 22:Number 1(2017)
• Page Start: 5
• Page End: 12
• Publication Date: 2017-02
• Subjects: ankle–brachial index -- inflammation -- lipoprotein-associated phospholipase A2 -- peripheral arterial disease (PAD); Blood-vessels -- Diseases -- Periodicals; Peripheral vascular diseases -- Periodicals; Vascular Diseases -- Periodicals; Vaisseaux sanguins -- Maladies -- Périodiques; Maladies vasculaires périphériques -- Périodiques; 616.13
• DOI: 10.1177/1358863X16671424
• Languages: English
• ISSNs: 1358-863X

Abstract

Prospective studies supporting a relationship between elevated lipoprotein-associated phospholipase A2 (Lp-PLA2 ) and incident peripheral arterial disease (PAD) are limited. We evaluated the association of Lp-PLA2 with incident PAD in a multi-ethnic cohort without clinical cardiovascular disease. A total of 4622 participants with measurement of Lp-PLA2 mass and Lp-PLA2 activity and an ankle–brachial index (ABI) between 0.9 and 1.4 were followed for the development of PAD (median follow-up = 9.3 years), defined as an ABI ⩽0.9 and decline from baseline ⩾0.15. There were 158 incident PAD events during follow-up. In adjusted logistic regression models, each higher standard deviation of both Lp-PLA2 activity and mass did not confer an increased risk of developing PAD [odds ratios, (95% confidence intervals)]: 0.92 (0.66–1.27) for Lp-PLA2 activity and 1.06 (0.85–1.34) for mass. Additionally, no significant interaction was found according to ethnicity: p =0.43 for Lp-PLA2 activity and p =0.55 for Lp-PLA2 mass. We found no evidence of an association between Lp-PLA2 and incident PAD.