Netrin-1 in cancer: Potential biomarker and therapeutic target?. Issue 4 (April 2017)

• Record Type: Journal Article
• Authors: Kefeli, Umut; Ucuncu Kefeli, Aysegul; Cabuk, Devrim; Isik, Ulas; Sonkaya, Alper; Acikgoz, Ozgur; Ozden, Ercan; Uygun, Kazim
• Is Part Of: Tumor biology. Volume 39:Issue 4(2017)
• Publication Date: 2017-04
• Subjects: Netrin-1 -- cancer -- biomarker -- therapeutic -- target -- dependence receptors; Cancer -- Periodicals; Oncology -- Periodicals; Tumors -- Periodicals; 616.994
• DOI: 10.1177/1010428317698388
• Languages: English
• ISSNs: 1010-4283

Abstract

Netrin-1, a laminin-related protein, is known to be involved in the nervous system development. Recently, Netrin-1's involvement in other processes such as cell adhesion, motility, proliferation, and differentiation that are important for the development of epithelial tissues has been described. In addition, Netrin-1 and its receptors, deleted in colorectal cancer and uncoordinated-5 homolog, have been linked to apoptosis and angiogenesis. Since these properties are essential for tumor development, Netrin-1 and its receptors have been reported to promote tumorigenesis in many types of cancers. Here, we review the Netrin-1 mediated regulation of cancer, its potential use as a biomarker, and the targeting of the Netrin-1 pathway to treat cancers.