Involvement of miR-125a in resistance to daunorubicin by inhibiting apoptosis in leukemia cell lines. Issue 4 (April 2017)

• Record Type: Journal Article
• Authors: Bai, Haitao; Zhou, Lili; Wang, Chun; Xu, Xiaowei; Jiang, Jieling; Qin, Youwen; Wang, Xiaorui; Zhao, Chuxian; Shao, Shan
• Is Part Of: Tumor biology. Volume 39:Issue 4(2017)
• Publication Date: 2017-04
• Subjects: MicroRNA-125a -- daunorubicin -- apoptosis -- leukemia; Cancer -- Periodicals; Oncology -- Periodicals; Tumors -- Periodicals; 616.994
• DOI: 10.1177/1010428317695964
• Languages: English
• ISSNs: 1010-4283

Abstract

In this study, we investigated whether miR-125a participated in the resistance of the leukemia cell lines to the chemotherapeutic agent daunorubicin. Higher expression of miR-125a is correlated with lower treatment response and shorter overall survival in acute leukemia patients. Overexpression of miR-125a induced drug resistance in HL-60, K562, and THP-1cell lines through reducing apoptosis. We also showed that miR-125a mediated daunorubicin resistance in leukemia cell lines through the decrease of GRK2 and Puma which were proved to be direct targets of miR-125a. This study may provide novel therapeutic targets for therapy and improve predictions of therapeutic responses in leukemia to daunorubicin.