Solid‐phase extraction of drugs with cuttlefish bone powder as a sorbent. Issue 18 (26th August 2018)

• Record Type: Journal Article
• Authors: Khazri, Hassen; Ghorbel‐Abid, Ibtissem; Debrauwer, Laurent; Kalfat, Rafik; Trabelsi‐Ayadi, Malika
• Is Part Of: Journal of separation science. Volume 41:Issue 18(2018)
• Page Start: 3547
• Page End: 3552
• Publication Date: 2018-08-26
• Subjects: cuttlefish bone powder -- drugs -- high‐performance liquid chromatography -- solid‐phase extraction; Separation (Technology) -- Periodicals; Chromatographic analysis -- Periodicals; 543.089
• DOI: 10.1002/jssc.201800419
• Languages: English
• ISSNs: 1615-9306

Abstract

Abstract: We investigated cuttlefish bone powder for the solid‐phase extraction of naproxen, ibuprofen, and carbamazepine. The basic principles controlling the extraction are presented to aid in the choice of the nature and quantity of the extracting phase according to the sample matrix and the solute properties, based on the mechanisms of phase retention. Their retention mechanism is based on hydrogen bonding and electrostatic interactions. The results show a significant recovery rate for the three drugs, selectivity, and low cost. The method has successfully reduced the amount of tested pharmaceuticals with recoveries >87% at pH 4.