2, 3-Diphosphoglycerate Concentrations in Autologous Salvaged Versus Stored Red Blood Cells in Surgical Patients After Transfusion. Issue 6 (December 2016)

• Record Type: Journal Article
• Authors: Scott, Andrew V.; Nagababu, Enika; Johnson, Daniel J.; Kebaish, Khaled M.; Lipsitz, Joshua A.; Dwyer, Ian M.; Zuckerberg, Gabriel S.; Barodka, Viachaslau M.; Berkowitz, Dan E.; Frank, Steven M.
• Is Part Of: Survey of anesthesiology. Volume 60:Issue 6(2016)
• Publication Date: 2016-12
• Subjects: Anesthesiology -- Periodicals; 617.96
• DOI: 10.1097/01.sa.0000508141.91805.f3
• Languages: English
• ISSNs: 0039-6206

Abstract

Abstract : (Abstracted from Anesth Analg, 122:616–623, 2016) Red blood cells (RBCs) undergo morphological and biochemical changes in structure during storage and are at risk of storage lesions and loss of 2, 3-diphosoglycerate (2, 3-DPG). In fact, 2, 3-DPG is nearly depleted after 21 days of storage, and although the issue is controversial, it is thought that reduced 2, 3-DPG may adversely affect oxygen delivery, seen through a shift of the oxyhemoglobin dissociation curve to the left and subsequent decrease in P50 (partial pressure of oxygen at which 50% of hemoglobin is saturated with O2 ).