Randomized Clinical Trial of 24% Oral Sucrose to Decrease Pain Associated With Peripheral Intravenous Catheter Insertion in Preterm and Term Newborns. (February 2017)

• Record Type: Journal Article
• Authors: Cook, Linda M.; Nichols-Dada, Jacinth; Damani, Samina; Lawrence, Vickie; Layson, Sandra; Mitchell, Diane; Muhammad, Shaqunna; Samaniego-Yamin, Lourdes; Talley, Jacquelyn Walters; VanNatta, Barbara; Higgins, Melinda; Cooley, Kim
• Other Names: Dowling Donna section editor.
• Is Part Of: Advances in neonatal care. Volume 17:Number 1(2017)
• Publication Date: 2017-02
• Subjects: IV -- pain -- RCT -- sucrose -- Sweet Aid; Newborn infants -- Medical care -- Periodicals; Newborn infants -- Diseases -- Nursing -- Periodicals; Premature infants -- Hospital care -- Periodicals; 618.9201
• DOI: 10.1097/ANC.0000000000000326
• Languages: English
• ISSNs: 1536-0903

Abstract

Abstract : Purpose: To determine whether 24% sucrose solution given orally before insertion of a peripheral intravenous (PIV) catheter decreases neonatal pain. Background: Prior studies of pain caused by heel and arterial needlesticks found oral administration of 24% sucrose to significantly blunt pain during these painful procedures. No studies have evaluated this treatment with needlestick pain associated with PIV catheter insertion. Methods: Oral 24% sucrose or placebo solution was administered 2 minutes prior to PIV catheter insertion. Outcome measures were obtained prior to, during, and for 5 minutes after PIV catheter insertion. Investigators and caregivers were blinded to group assignment. Data were analyzed with longitudinal analysis of repeated measures, with P < .05 for significance. Results: A total of 40 neonates (24% sucrose: N = 20; placebo: N = 20) were studied. Pain scores significantly increased from 3.2 ± 1.6 to a maximum of 7.6 ± 3.8 at the time of catheter insertion, returning to baseline levels 8 minutes after PIV catheter insertion ( P < .001). No significant differences were found in pain, heart rate, or noninvasive oxygen saturation (SpO2 ) between the sucrose and placebo groups ( P > 0.05). Implications for Practice: Results from this study did not find that 24% sucrose administered prior to PIV catheter insertion altered the infant's pain response. Implications for Research: Since this is the first study to evaluate the pain-blunting effects of 24% sucrose administration before PIV catheter insertion, replication of this study is needed before widespread application of findings.