Hemostatic Efficacy of Nanofibrous Matrix in Rat Liver Injury Model. (February 2017)

• Record Type: Journal Article
• Authors: Jaiswal, Amit K.; Chhabra, Hemlata; Narwane, Sandipan; Rege, Nirmala; Bellare, Jayesh R.
• Is Part Of: Surgical innovation. Volume 24:Number 1(2017:Feb.)
• Page Start: 23
• Page End: 28
• Publication Date: 2017-02
• Subjects: hemostasis -- liver injury -- electrospinning -- gelatin -- polycaprolactone; Surgery, Operative -- Periodicals; Endoscopic surgery -- Periodicals; Laparoscopic surgery -- Periodicals; Surgical Procedures, Operative -- Periodicals; Surgical Procedures, Minimally Invasive -- Periodicals; Diffusion of Innovation -- Periodicals; Chirurgie opératoire -- Périodiques; Chirurgie endoscopique -- Périodiques; Chirurgie laparoscopique -- Périodiques; 617.91
• DOI: 10.1177/1553350616675799
• Languages: English
• ISSNs: 1553-3506

Abstract

This present study examined the hemostatic efficacy of nanofibrous matrix in a rat liver model. The nanofibrous matrix comprising gelatin and polycaprolactone was prepared by electrospinning method. Twelve animals underwent surgery and were followed-up for a month. Time taken to cease bleeding, activated partial thromboplastin time, prothrombin time, and fibrinogen concentration were measured. Histopathological examination of liver was also done of treated and control animals. All test animals showed very rapid hemostasis after application of electrospun sheet. Histopathological study showed quick recovery of liver wound in the test group as compared to the control group. The nanofibrous matrix has proven to be not only safe and effective as hemostat but has also shown its potential for liver regeneration.