Missed treatment in an Italian HBV infected patients cohort: HBV RER. Issue 11 (November 2016)

• Record Type: Journal Article
• Authors: Ferrari, C.; Giuberti, T.; Villa, E.; Andreone, P.; Pietrangelo, A.; Abbati, G.; Magnani, G.; Massari, M.; Verucchi, G.; Cancellieri, C.; Ricca Rosellini, S.; Levantesi, F.; Mazzella, G.; Sacchini, D.; Fornaciari, G.; Mussini, C.; Borghi, V.; Foschi, F.; Libanore, M.; Carradori, S.D.; Contini, C.; Ballardini, G.; Macchia, S.; Boccia, S.; Vandelli, C.; Bassi, P.; Zanotti, M.; Loria, P.; Sbolli, G.; Fornari, F.; di Maira, P.V.; Bellentani, S.; Arlotti, M.; Grosso, C.; Bolondi, G.; Pazzi, P.; Mazzocchi, A.; Govoni, A.; Fusaroli, P.; Giacomoni, P.L.; Lenzi, M.; Pedretti, G.; Cuomo, Gianluca; Borghi, Vanni; Andreone, Pietro; Massari, Marco; Villa, Erica; Pietrangelo, Antonello; Verucchi, Gabriella; Ferrari, Carlo;
• Is Part Of: Digestive and liver disease. Volume 48:Issue 11(2016)
• Page Start: 1346
• Page End: 1350
• Publication Date: 2016-11
• Subjects: HBV -- Hepatitis B treatment -- Liver fibrosis; Digestive organs -- Diseases -- Periodicals; Liver -- Diseases -- Periodicals; 616.33005
• DOI: 10.1016/j.dld.2016.07.016
• Languages: English
• ISSNs: 1590-8658

Abstract

Abstract: Background and aims: Very little is known about the access to treatment for Chronic Hepatitis B in the real clinical practice and the characteristics of the patients who do not receive antiviral therapy. Methods: HBV-RER is an observational multicenter network that collected data of patients with HBV infection during a 3 years observational period (2009–2012). Results: Among 2527 HBsAg positive patients, 1099 were never treated (NT); only 280 were included in the analysis due to different exclusion causes A minority was HBeAg-positive. The median age was 42. At liver biopsy most patients had Metavir score of F0-F1. Univariate analysis between 280 NT patients and the 290 naïve to treatment showed that NT patients were mostly female ( P = 0.002), not Italian ( P = 0.044), younger ( P < 0.001). Metavir score was lower in NT (P0.002), such as the Fib4 score ( P < 0.001). HBV DNA level was significantly higher in NT. At multivariate analysis, independent variables associated with no-treatment were younger age, female gender, Metavir score F0-F1, Fib4 lower than 1.6 and lower blood level of HBV-DNA. Conclusions: There is a large number of patients eligible to treatment who do not receive it. A younger age and a less severe disease seem to be associated to deferral of treatment.