Addressing the challenges of phenotyping pediatric pulmonary vascular disease. (January 2017)

• Record Type: Journal Article
• Authors: Goss, Kara N.; Everett, Allen D.; Mourani, Peter M.; Baker, Christopher D.; Abman, Steven H.
• Is Part Of: Pulmonary circulation. Volume 7:Number 1(2017)
• Page Start: 7
• Page End: 19
• Publication Date: 2017-01
• Subjects: childhood -- pulmonary hypertension -- registry studies -- long-term outcomes; Pulmonary circulation -- Periodicals; Pulmonary circulation; Electronic journals -- Sciences; Periodicals; 616.24005
• DOI: 10.1086/689750
• Languages: English
• ISSNs: 2045-8932

Abstract

Pediatric pulmonary vascular disease (PVD) and pulmonary hypertension (PH) represent phenotypically and pathophysiologically diverse disease categories, contributing substantial morbidity and mortality to a complex array of pediatric conditions. Here, we review the multifactorial nature of pediatric PVD, with an emphasis on improved recognition, phenotyping, and endotyping strategies for pediatric PH. Novel tailored approaches to diagnosis and treatment in pediatric PVD, as well as the implications for long-term outcomes, are highlighted.