Pentraxin 3 and other inflammatory biomarkers related to atrial fibrillation in cardiac surgery. (May 2017)

• Record Type: Journal Article
• Authors: Holubcova, Zdenka; Kunes, Pavel; Mandak, Jiri; Vlaskova, Dana; Kolackova, Martina; Holmannova, Drahomira; Andrys, Ctirad; Krejsek, Jan; Holubec, Tomas
• Is Part Of: Perfusion. Volume 32:Number 4(2017)
• Page Start: 269
• Page End: 278
• Publication Date: 2017-05
• Subjects: cardiac surgery -- atrial fibrillation -- inflammation -- biomarker -- pentraxin 3; Perfusion (Physiology) -- Periodicals; Blood -- Circulation, Artificial -- Periodicals; Heart -- Surgery -- Periodicals; Extracorporeal Circulation -- Periodicals; Perfusion -- Periodicals; Circulation extracorporelle -- Périodiques; Perfusion -- Périodiques; 617.41
• DOI: 10.1177/0267659116679248
• Languages: English
• ISSNs: 0267-6591

Abstract

Objectives: The aim was to evaluate the association between perioperative inflammatory biomarkers and atrial fibrillation (AF) in cardiac surgical patients. Methods: Forty-two patients undergoing cardiac surgery were divided into three groups according to the occurrence of AF: Group A (n = 22) – patients with no AF, Group B (n = 11) – patients with new onset AF postoperatively and Group C (n = 9) – patients with preoperative history of atrial fibrillation. The serum levels of PTX3, CRP, TLR2, IL-8, IL-18, sFas, MMP-7 and MMP-8 were measured at the following time points: before surgery, immediately and 6 h after surgery and on the 1 st, 3 rd and 7 th postoperative days (POD). Results: Serum levels of PTX3 showed a significant difference between Groups A and C on the 3 rd POD (p<0.05) and on the 7 th POD (p<0.0001). IL-8 levels were different between Groups A and C immediately after surgery (p<0.05), 6 hours after surgery (p<0.05) and on the 3 rd POD (p<0.05). There was a difference between Groups B and C on the 1 st POD in IL-8 levels (p<0.05). The sFas levels differed between Groups A and C on the 3 rd POD (p<0.01) and the 7 th POD (p<0.05). There was also a difference on the 7 th POD (p<0.05) between the Groups B and C. No significant differences between the groups was seen for other biomarkers. Conclusion: This study demonstrates significantly different dynamics of PTX3, IL-8 and sFas levels after cardiac surgery in relation to AF.