Synthesis and Characterization of PEG‐PBS Copolymers to Obtain Microspheres With Different Naproxen Release Profiles. Issue 1 (16th August 2018)

• Record Type: Journal Article
• Authors: Ramon, Jose; Saez, Vivian; Gomes, Fernando; Pinto, Jose; Nele, Marcio
• Other Names: Gomes Fernando guestEditor.; Thomas Sabu guestEditor.; Toledo Romildo guestEditor.; Pinto Jose Carlos guestEditor.
• Is Part Of: Macromolecular symposia. Volume 380:Issue 1(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-08-16
• Subjects: mathematical models for drug delivery -- microencapsulation -- naproxen -- poly(butylene succinate‐co‐polyethylene glycol -- polycondensation; Macromolecules -- Congresses; Polymers -- Congresses; Polymerization -- Congresses; Macromolecules -- Periodicals; Polymers -- Periodicals; Polymerization -- Periodicals; 547.705
• DOI: 10.1002/masy.201800065
• Languages: English
• ISSNs: 1022-1360

Abstract

Abstract : Researching for new biomaterials intended for drug delivery systems has considerably intensified in recent years. There is an increasing interest in PBS (poly[butylene succinate]) and its copolymers as biomaterials due to the possibility of synthesis of the PBS from a renewable source. Among these copolymers, PBS‐PEG (poly[butylene succinate‐co‐polyethylene glycol]) is studied for materials that have shape memory and are biodegradable. However, to date, no research into the use of PBS‐PEG to prepare microspheres for drugs release has been reported. Herein, PBS‐PEGs with three PEG with different chain′s length were synthesized by polycondensation reaction and characterized by means of SEC, FTIR, DSC, TGA, and DRX. Naproxen loaded microspheres were prepared by an oil‐in‐water (o/w) single emulsion technique. The drug release was followed by UV‐Vis. The presence of PEG had a marked effect on the in vitro release profiles. The mathematical models employed show that the fundamental mechanism of release is diffusion when PEG is present in the polymer matrix of the particle.