Biotechnological production of alpha-keto acids: Current status and perspectives. (November 2016)

• Record Type: Journal Article
• Authors: Song, Yang; Li, Jianghua; Shin, Hyun-dong; Liu, Long; Du, Guocheng; Chen, Jian
• Is Part Of: Bioresource technology. Volume 219(2016)
• Page Start: 716
• Page End: 724
• Publication Date: 2016-11
• Subjects: α-Keto acid -- Pyruvate -- α-Ketoglutarate -- α-Ketoisovalerate -- α-Ketoisocaproate -- α-Keto-γ-methylthiobutyrate -- 2, 5-Diketo-d-gluconate; Biomass -- Periodicals; Biomass energy -- Periodicals; Bioremediation -- Periodicals; Agricultural wastes -- Periodicals; Factory and trade waste -- Periodicals; Organic wastes -- Periodicals; Bioénergie -- Périodiques; Déchets agricoles -- Périodiques; Déchets industriels -- Périodiques; Déchets organiques -- Périodiques; Déchets (Combustible) -- Périodiques; 662.88
• DOI: 10.1016/j.biortech.2016.08.015
• Languages: English
• ISSNs: 0960-8524

Abstract

Highlights: Present the different types of α-keto acids as well as their applications. Summarize the recent progresses in the production of some important α-keto acids. Discuss the future prospects for the production of keto acids. Abstract: Alpha-keto (α-keto) acids are used widely in feeds, food additives, pharmaceuticals, and in chemical synthesis processes. Although most α-keto acids are currently produced by chemical synthesis, their biotechnological production from renewable carbohydrates is a promising new approach. In this mini-review, we first present the different types of α-keto acids as well as their applications; next, we summarize the recent progresses in the biotechnological production of some important α-keto acids; namely, pyruvate, α-ketoglutarate, α-ketoisovalerate, α-ketoisocaproate, phenylpyruvate, α-keto-γ-methylthiobutyrate, and 2, 5-diketo-d -gluconate. Finally, we discuss the future prospects as well as favorable directions for the biotechnological production of keto acids that ultimately would be more environment-friendly and simpler compared with the production by chemical synthesis.