Placental Mesenchymal Dysplasia without Fetal Development in a Twin Gestation: A Case Report and Review of the Spectrum of Androgenetic Biparental Mosaicism. (March 2015)

• Record Type: Journal Article
• Authors: Linn, Rebecca L.; Minturn, Lucy; Yee, Lynn M.; Maniar, Kruti; Zhang, Yanming; Fritsch, Michael K.; Kashireddy, Papreddy; Kapur, Raj; Ernst, Linda M.
• Is Part Of: Pediatric and developmental pathology. Volume 18:Number 2(2015)
• Page Start: 146
• Page End: 154
• Publication Date: 2015-03
• Subjects: androgenetic biparental mosaicism -- hydatidiform mole -- placental mesenchymal dysplasia; Pediatric pathology -- Periodicals; Children -- Diseases -- Periodicals; Diagnosis, Laboratory -- Periodicals; Abnormalities, Human -- Periodicals; Child development -- Periodicals; Pediatrics -- Periodicals; 616.07
• DOI: 10.2350/14-12-1583-CR.1
• Languages: English
• ISSNs: 1093-5266

Abstract

We report a dichorionic twin gestation with diffuse placental mesenchymal dysplasia (PMD) and androgenetic biparental mosaicism (ABM) involving one twin's placenta with complete absence of fetal development for that twin. To our knowledge, this is the 1st reported case of PMD without fetal development. We discuss the gross, histologic, and genetic hallmarks of PMD and the spectrum of variability depending on degree and distribution of ABM.