Can Platelet-Rich Plasma Protect Rat Achilles Tendons From the Deleterious Effects of Triamcinolone Acetonide?. Issue 7 (7th July 2015)

• Record Type: Journal Article
• Authors: Muto, Tomoyuki; Kokubu, Takeshi; Mifune, Yutaka; Inui, Atsuyuki; Sakata, Ryosuke; Harada, Yoshifumi; Takase, Fumiaki; Ueda, Yasuhiro; Kuroda, Ryosuke; Kurosaka, Masahiro
• Is Part Of: Orthopaedic journal of sports medicine. Volume 3:Issue 7(2015:Jul.)
• Publication Date: 2015-07-07
• Subjects: triamcinolone acetonide -- platelet-rich plasma -- rat Achilles tendon -- corticosteroid injection; Sports medicine -- Periodicals; Orthopedics -- Periodicals; Arthroscopy -- Periodicals; Arthroplasty -- Periodicals; Knee -- Surgery -- Periodicals; 616.7
• DOI: 10.1177/2325967115590968
• Languages: English
• ISSNs: 2325-9671

Abstract

Background: Triamcinolone acetonide (TA) injections are widely used for tendinitis but have deleterious effects, including tendon degeneration or tendon rupture. Purpose: To investigate whether adding platelet-rich plasma (PRP), a blood fraction that participates in tissue repair processes, to TA can prevent its deleterious effects. Study Design: Controlled laboratory study. Methods: Rat Achilles tendons were injected with TA, TA + PRP, PRP alone, or saline (control). Biomechanical testing and histological analyses were performed on Achilles tendons 1 week after injections. Results: The maximum failure loads in the control, TA, TA + PRP, and PRP groups were 31.7 ± 2.3, 19.0 ± 3.6, 31.0 ± 7.1, and 30.2 ± 6.8 N, respectively. The tendon stiffness in the control, TA, TA + PRP, and PRP groups was 12.1 ± 1.8, 7.5 ± 1.8, 11.0 ± 2.8, and 11.3 ± 2.5 N/mm, respectively. The maximum failure load and stiffness were significantly lower in the TA group compared with the other 3 groups. There was no significant difference between the TA + PRP and control groups. Cell invasions, vacuolation, collagen attenuation, and increased type III collagen expression were histologically observed in the TA group; however, these changes were prevented by the simultaneous administration of PRP. Conclusion: Administering PRP may prevent deleterious effects caused by TA; therefore, PRP may be used as a protective agent in clinical situations. Clinical Relevance: PRP can be useful as a protective agent for sports injury patients receiving local corticosteroid injections.