The human genital tubercle is steroidogenic organ at early pregnancy. (5th December 2018)

• Record Type: Journal Article
• Authors: Savchuk, I.; Morvan, M.L.; Antignac, J.P.; Gemzell-Danielsson, K.; Le Bizec, B.; Söder, O.; Svechnikov, K.
• Is Part Of: Molecular and cellular endocrinology. Volume 477(2018)
• Page Start: 148
• Page End: 155
• Publication Date: 2018-12-05
• Subjects: Human fetal tubercle -- Steroidogenic enzyme expression -- Steroid profiles; Endocrinology -- Periodicals; Molecular biology -- Periodicals; Cytology -- Periodicals; Endocrinology -- Periodicals; Hormones -- Periodicals; Endocrinologie -- Périodiques; Cytology; Endocrinology; Molecular biology; Periodicals; 573.4
• DOI: 10.1016/j.mce.2018.06.012
• Languages: English
• ISSNs: 0303-7207

Abstract

Abstract: It is generally accepted that androgens produced by fetal Leydig cells (FLC) control proper masculinization of the male external genitalia. Here, we hypothesized that the human genital tubercle (GT) has potential to synthesize androgens independently of FLC at early pregnancy. We observed that human GT of both genders have capacity to synthesize steroids of the Δ 4, Δ 5 and alternative pathway of DHT synthesis including the androgen itself. The presence of steroids in the GT was associated with the expression of corresponding steroidogenic enzymes. Levels of steroids and the expression of steroidogenic enzymes were similar in the GT from male and female fetuses. In contrast to the GT, the human fetal testis synthesized DHT from testosterone but not via the alternative pathway. Our findings strongly suggest that the human GT at early pregnancy can synthesize DHT via the alternative pathway, which may play an important role in organogenesis of the urethra. Highlights: Human genital tubercle has potential to synthesize sex steroids. Human genital tubercle can synthesize DHT via the backdoor pathway. Human genital tubercle expresses multiple steroidogenic enzymes.