Catalytic enantioselective and regioselective substitution of 2, 3-indolyldimethanols with enaminones. Issue 18 (14th August 2018)

• Record Type: Journal Article
• Authors: Lu, Yi-Nan; Ma, Chun; Lan, Jin-Ping; Zhu, Caiqiang; Mao, Yu-Jia; Mei, Guang-Jian; Zhang, Shu; Shi, Feng
• Is Part Of: Organic chemistry frontiers. Volume 5:Issue 18(2018)
• Page Start: 2657
• Page End: 2667
• Publication Date: 2018-08-14
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/c8qo00565f
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : 2, 3-Indolyldimethanols as a new class of indolyldimethanols have been designed, and the first catalytic asymmetric substitution of 2, 3-indolyldimethanols has been established by using cyclic enaminones as nucleophiles. Abstract : 2, 3-Indolyldimethanols as a new class of indolyldimethanols have been designed, and the first catalytic asymmetric substitution of 2, 3-indolyldimethanols has been established by using cyclic enaminones as nucleophiles, which afforded substitutive products in an enantioselective and regioselective mode (up to 98% ee, all >95 : 5 rr). This reaction represents the first design and application of 2, 3-indolyldimethanols in catalytic asymmetric reactions, which will greatly enrich the chemistry of indolyldimethanols.