A facile synthesis of diverse 5-arylated triazoles via a Cu-catalyzed oxidative interrupted click reaction with arylboronic acids in air. Issue 16 (17th July 2018)

• Record Type: Journal Article
• Authors: Yu, Xiaoxia; Xu, Jian; Zhou, Yao; Song, Qiuling
• Is Part Of: Organic chemistry frontiers. Volume 5:Issue 16(2018)
• Page Start: 2463
• Page End: 2467
• Publication Date: 2018-07-17
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/c8qo00590g
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : A Cu-catalyzed synthesis of 5-arylsubstituted 1, 2, 3-triazoles via an oxidative interrupted click reaction with arylboronic acids in air at room temperature is disclosed. Abstract : We herein disclose a Cu-catalyzed synthesis of 5-arylsubstituted 1, 2, 3-triazoles via an oxidative interrupted click reaction, using air as the sole terminal oxidant. The current protocol provides a novel method for the one-step construction of fully substituted triazoles in good yields under mild conditions, in which arylboronic acids are employed as aromatic sources to interrupt the cuprate–triazole intermediate for the first time.