An NIR-triggered and thermally responsive drug delivery platform through DNA/copper sulfide gates. Issue 29 (6th July 2015)

• Record Type: Journal Article
• Authors: Zhang, Lei; Li, Yecheng; Jin, Zexun; Yu, Jimmy C.; Chan, King Ming
• Is Part Of: Nanoscale. Volume 7:Issue 29(2015)
• Page Start: 12614
• Page End: 12624
• Publication Date: 2015-07-06
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/c5nr02767e
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : Nanomaterials for effective drug delivery that exhibit temperature and NIR-responsive DOX release. Abstract : Nanomaterials for effective drug delivery require zero pre-release and on-demand release of therapeutic drugs. In this work we demonstrate a novel drug delivery system composed of a mesoporous silica platform conjugated to CuS nanoparticles with two complementary DNA sequences. CuS nanoparticles act as both gatekeepers preventing pre-release of drugs and photothermal agents for effective killing of cancer cells. This system exhibits temperature and NIR-responsive DOX release, with an additional accelerated release rate with GSH treatment. Therefore, it can act as an effective anticancer drug delivery carrier with triggered drug release and efficient anti-cancer effect in vitro after NIR irradiation.