Various physicochemical and surface properties controlling the bioactivity of cerium oxide nanoparticles. (3rd October 2018)

• Record Type: Journal Article
• Authors: Chen, Bing-Huei; Stephen Inbaraj, Baskaran
• Is Part Of: Critical reviews in biotechnology. Volume 38:Number 7(2018)
• Page Start: 1003
• Page End: 1024
• Publication Date: 2018-10-03
• Subjects: Cerium oxide nanoparticles -- physicochemical properties -- surface properties -- cellular uptake -- sub-cellular localization -- cytotoxicity; Biotechnology -- Periodicals; Biotechnology -- Periodicals; Review Literature -- Periodicals; Public Health -- Periodicals; Environment -- Periodicals; Industry -- Periodicals; Biotechnology; Review Literature; Public Health; Environment; Industry; 660.6
• DOI: 10.1080/07388551.2018.1426555
• Languages: English
• ISSNs: 0738-8551

Abstract

Abstract: Amidst numerous emerging nanoparticles, cerium oxide nanoparticles (CNPs) possess fascinating pharmacological potential as they can be used as a therapeutic for various oxidative stress-associated chronic diseases such as cancer, inflammation and neurodegeneration due to unique redox cycling between Ce 3+ and Ce 4+ oxidation states on their surface. Lattice defects generated by the formation of Ce 3+ ions and compensation by oxygen vacancies on CNPs surface has led to switching between CeO2 and CeO2–x during redox reactions making CNPs a lucrative catalytic nanoparticle capable of mimicking key natural antioxidant enzymes such as superoxide dismutase and catalase. Eventually, most of the reactive oxygen species and nitrogen species in biological system are scavenged by CNPs via an auto-regenerative mechanism in which a minimum dose can exhibit catalytic activity for a longer duration. Due to the controversial outcomes on CNPs toxicity, considerable attention has recently been drawn towards establishing relationships between the physicochemical properties of CNPs obtained by different synthesis methods and biological effects ranging from toxicity to therapeutics. Unlike non-redox active nanoparticles, variations in physicochemical properties and the surface properties of CNPs obtained from different synthesis methods can significantly affect their biological activity (inactive, antioxidant, or pro-oxidant). Moreover, these properties can influence the biological identity, cellular interactions, cellular uptake, biodistribution, and therapeutic efficiency. This review aims to highlight the critical role of various physicochemical and the surface properties of CNPs controlling their biological activity based on 165 cited references.