Stepwise Drug‐Release Behavior of Onion‐Like Vesicles Generated from Emulsification‐Induced Assembly of Semicrystalline Polymer Amphiphiles. (18th June 2015)

• Record Type: Journal Article
• Authors: Park, Mi‐Kyoung; Jun, Sangmi; Kim, Inhye; Jin, Seon‐Mi; Kim, Jin‐Gyu; Shin, Tae Joo; Lee, Eunji
• Is Part Of: Advanced functional materials. Volume 25:Number 29(2015)
• Page Start: 4570
• Page End: 4579
• Publication Date: 2015-06-18
• Subjects: electron tomography -- hydrolytic degradation -- onion‐like vesicles -- self‐assembly -- semicrystalline polymers; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.201501595
• Languages: English
• ISSNs: 1616-301X

Abstract

Abstract : Tailoring unique nanostructures of biocompatible and degradable polymers and the consequent elucidation of shape effects in drug delivery open tremendous opportunities not only to broaden their biomedical applications but also to identify new directions for the design of nanomedicine. Cellular organelles provide the basic structural and functional motif for the development of novel artificial nanoplatforms. Herein, aqueous onion‐like vesicles structurally mimicking multicompartmentalized cellular organelles by exhibiting exquisite control over the molecular assembly of poly(ethylene oxide)‐ block ‐poly( ε ‐caprolactone) (PEO‐ b ‐PCL) semicrystalline amphiphiles are reported. Compared to in situ self‐assembly, emulsification‐induced assembly endows the resulting nanoaggregates of PEO‐ b ‐PCL with structural diversity such as helical ribbons and onion‐like vesicles through the molecular packing modification in the hydrophobic core with a reduction of inherent crystalline character of PCL. In particular, onion‐like vesicles composed of alternating walls and water channels are interpreted by nanometer‐scale 3D visualization via cryogenic‐electron tomo­graphy (cryo‐ET). Interestingly, the nature of the multi‐walled vesicles results in high drug‐loading capacity and stepwise drug release through hydrolytic cleavage of the PCL block. The crystalline arrangement of PCL at the molecular scale and the spatial organization of assembled structure at the nanoscale significantly affect the drug‐release behavior of PEO‐ b ‐PCL nanovehicles. Abstract : Tailoring unique nanostructures of biocompatible and degradable polymers and elucidating their shape effects in drug delivery open tremendous opportunities to not only broaden their biomedical applications but also to identify new directions for designing nanomedicine. The exquisite fabrication of onion‐like vesicles, based on the assembly of poly(ethylene oxide)‐ block ‐poly( ε ‐caprolactone), allows stepwise anticancer drug release through the sequential hydrolytic cleavage of multi‐walls.