Metagenomics analysis of the virome of 300 concentrates from a Swiss platelet bank. Issue 6 (18th July 2018)

• Record Type: Journal Article
• Authors: Brito, Francisco; Cordey, Samuel; Delwart, Eric; Deng, Xutao; Tirefort, Diderik; Lemoine‐Chaduc, Coralie; Zdobnov, Evgeny; Lecompte, Thomas; Kaiser, Laurent; Waldvogel‐Abramowski, Sophie; Preynat‐Seauve, Olivier
• Is Part Of: Vox sanguinis. Volume 113:Issue 6(2018)
• Page Start: 601
• Page End: 604
• Publication Date: 2018-07-18
• Subjects: next‐generation sequencing -- platelet concentrates -- transfusion‐transmissible infections; Blood -- Periodicals; Blood -- Transfusion -- Periodicals; Immunohematology -- Periodicals; Immunopathology -- Periodicals; 615.39
• DOI: 10.1111/vox.12695
• Languages: English
• ISSNs: 0042-9007

Abstract

Abstract : Background and objectives: Platelet concentrates are frequently transfused to patients with reduced immunity. An exhaustive description of their viral content is needed to prevent unwanted infection. Material and methods: To track viral sequences, a shotgun metagenomics approach was used on a bank of 300 platelets concentrates. Sequences were analysed through the diagnostics‐oriented pipeline ezVIR. Results: We only observed viruses commonly described in healthy individuals. Conclusion: Herein is reported the first viral landscape of a platelet concentrates bank.