Residue analysis and dietary exposure risk assessment of tebufenozide in stem lettuce (Lactuca sativa L. var. angustana Irish). (October 2018)

• Record Type: Journal Article
• Authors: Lin, Hongfang; Liu, Xinze; Ma, Yecheng; Pang, Kyongjin; Hu, Jiye
• Is Part Of: Food and chemical toxicology. Volume 120(2018)
• Page Start: 64
• Page End: 70
• Publication Date: 2018-10
• Subjects: Tebufenozide -- Dietary exposure risk assessment -- Stem lettuce -- LC-MS/MS; ADI acceptable daily intake -- ARfD acute reference dose -- bw the average body weight -- Fi the reference food intake -- GAP good agricultural practices -- HR the highest residue -- LC-MS/MS liquid chromatography-tandem mass spectrometry -- LOQs limits of quantification -- MRLs maximum residue limits -- NEDI national estimated daily intake -- NESTI international estimated short-term intake -- PHI pre-harvest interval -- RQ risk quotient -- RQc chronic dietary exposure risk probability -- RQa acute dietary exposure risk probability -- RSDs relative standard deviations -- SC suspension concentration -- STMR supervised trials median residue -- SPE solid-phase extraction; Toxicology -- Periodicals; Food poisoning -- Periodicals; Food Poisoning -- Periodicals; Toxicology -- Periodicals; Toxicologie -- Périodiques; Intoxications alimentaires -- Périodiques; Food poisoning; Toxicology; Periodicals; Electronic journals; 615.9
• DOI: 10.1016/j.fct.2018.06.057
• Languages: English
• ISSNs: 0278-6915

Abstract

Abstract: Tebufenozide, a newly-developed nonsteroidal ecdysone agonist, is in pre-regulation phase (before approval for use) on stem lettuce in China. Aiming at the safe application of tebufenozide, the dissipation and terminal residue trials on stem lettuce were performed under good agricultural practice (GAP). The dissipation trials shown that tebufenozide was rapidly degraded in stem lettuce, with half-lives of 5.0–8.2 days. Pre-regulation dietary exposure risk assessments were evaluated to recommend maximum residue limits (MRLs) based on risk quotients (RQ) method. Relevant toxicological parameters including ADI (acceptable daily intake) and ARfD (acute reference dose) were applied to assess the potential dietary exposure risk. The results indicated the chronic dietary exposure risk probability (RQc) of tebufenozide ranged from 36.4% to 70.0%. The acute dietary exposure risk probability (RQa) of tebufenozide was 2.88%–8.49% in lettuce stems and 14.0%–20.0% in lettuce leaves, respectively. On the basis of supervised field trial data and dietary exposure risk assessment results, the MRLs of tebufenozide were recommended as 3 mg/kg for lettuce stems and 10 mg/kg for lettuce leaves, respectively. The results demonstrated that the dietary exposure risk of tebufenozide used in stem lettuce under GAP was negligible and would not pose unacceptable health risk to Chinese consumers. Highlights: A reliable analytical method for determination of tebufenozide was developed. Supervised field trials of tebufenozide on stem lettuce were performed in China. Dietary exposure risk quotient of tebufenozide in stem lettuce was below 100%. MRL of tebufenozide was proposed as 3 mg/kg for lettuce stems. MRL of tebufenozide was proposed as 10 mg/kg for lettuce leaves.