Associations of coffee, tea and caffeine intake with risk of breast, endometrial and ovarian cancer among Canadian women. (October 2018)

• Record Type: Journal Article
• Authors: Arthur, Rhonda; Kirsh, Victoria A.; Rohan, Thomas E.
• Is Part Of: Cancer epidemiology. Volume 56(2018:Oct.)
• Page Start: 75
• Page End: 82
• Publication Date: 2018-10
• Subjects: Coffee -- Tea -- Caffeine -- Breast cancer -- Endometrial cancer -- Ovarian cancer; Cancer -- Epidemiology -- Periodicals; Cancer -- Prevention -- Periodicals; Cancer -- Diagnosis -- Periodicals; Carcinogenesis -- Periodicals; 616.994005
• DOI: 10.1016/j.canep.2018.07.013
• Languages: English
• ISSNs: 1877-7821

Abstract

Highlights: Total coffee, caffeinated coffee and caffeine intake were associated with lower risk of endometrial cancer. Higher caffeinated coffee intake may be positively, but weakly, associated with risk of premenopausal breast cancer. Total/caffeinated coffee and caffeine may be positively associated with risk of breast cancer among normal weight women. Larger prospective studies with information on type of coffee/tea and methods of preparation are needed to confirm our results. Abstract: Background: Although, biologically plausible evidence has implicated coffee, tea and caffeine with carcinogenesis, there is a paucity of data on their associations with risk of cancer among Canadian women. Hence, we assessed their associations with risk of breast, endometrial and ovarian cancers within this population. Methods: The study comprised a subcohort of 3185 women from a cohort of 39, 532 female participants who completed self-administered lifestyle and dietary questionnaires at enrollment. During a median follow-up of approximately 12.2years, we ascertained 922, 180 and 104 breast, endometrial and ovarian cancer cases, respectively. We used Cox proportional hazards regression models modified for the case-cohort design to estimate the hazard ratios (HR) and 95% confidence intervals (CI) for the associations of coffee, tea and caffeine with risk of selected cancers. Results: Coffee, tea, and caffeine intake were not associated with overall risk of breast and ovarian cancers. There was, however, a tendency towards an increased risk of breast cancer with increasing levels of total coffee, caffeinated coffee and/or caffeine among premenopausal and normal weight women. Total coffee, caffeinated coffee, and caffeine were inversely associated with risk of endometrial cancer (HRper cup increase : 0.88; 95% CI: 0.79-0.95, HRper cup increase: 0.88; 95% CI: 0.80-0.96 and HRper 100mg increase: 0.93; 95% CI: 0.87-0.99, respectively). Conclusion: Our findings suggest that coffee and/or caffeine may be associated with reduced risk of endometrial cancer but, probably, associated increased with risk of breast cancer among premenopausal or normal weight women. However, further studies are needed to confirm our findings.