Anti-inflammatory and cytotoxic withanolides from Physalis minima. (November 2018)

• Record Type: Journal Article
• Authors: Wu, Jiangping; Li, Xia; Zhao, Jianping; Wang, Ruijuan; Xia, Zifei; Li, Xiaoran; Liu, Yanli; Xu, Qiongming; Khan, Ikhlas A.; Yang, Shilin
• Is Part Of: Phytochemistry. Volume 155(2018)
• Page Start: 164
• Page End: 170
• Publication Date: 2018-11
• Subjects: Physalis minima L. (Solanaceae) -- Withanolides -- Anti-inflammatory -- Cytotoxic activity; Botanical chemistry -- Periodicals; Biochemistry -- Periodicals; Botany -- Periodicals; Chimie végétale -- Périodiques; 572.2
• DOI: 10.1016/j.phytochem.2018.08.009
• Languages: English
• ISSNs: 0031-9422

Abstract

Abstract: Six undescribed withanolides were isolated and characterized during the investigation of anti-inflammatory and cytotoxic constituents from the whole plants of Physalis minima L. Their structures were elucidated by extensive spectroscopic analyses (IR, UV, HR-ESI-MS, 1D-NMR, and 2D-NMR), and their anti-inflammatory and cytotoxic activities were evaluated in vitro . All the compounds exhibited anti-inflammatory ability via inhibiting the production of nitric oxide (NO) in lipopolysaccharide (LPS)-stimulated murine macrophage RAW 264.7 cells. Moderate cytotoxic activities against A549 lung adenocarcinoma cells, SMMC-7721 hepatic carcinoma cells and MCF-7 breast cancer cells with IC50 values in the range of 40.01–82.17 μM were observed for these withanolides. Graphical abstract: Highlights: Six undescribed withanolides were isolated from the whole plants of Physalis minima L. Their structures were elucidated by spectroscopic techniques. All these withanolides exhibited both anti-inflammatory and moderate cytotoxic activities.