Valvular involvement in granulomatosis with polyangiitis: Case report and systematic review of literature. Issue 9 (8th July 2018)

• Record Type: Journal Article
• Authors: Al‐Habbaa, Ahmed; Rawla, Prashanth; Morra, Mostafa Ebraheem; Abotaha, Ahmed Ahmed; Sakr, Eman El‐Sayed; Abdo Shehata, Mostafa Ahmed; Shahin, Karim Mohamed; Abdel Mageed, Sarah; Huy, Nguyen Tien
• Is Part Of: Echocardiography. Volume 35:Issue 9(2018)
• Page Start: 1456
• Page End: 1463
• Publication Date: 2018-07-08
• Subjects: endocardial valves -- Granulomatosis with polyangiitis -- Tricuspid valve -- Wegener's granulomatosis; Echocardiography -- Periodicals; Echocardiography -- Periodicals; 616.1207543
• DOI: 10.1111/echo.14094
• Languages: English
• ISSNs: 0742-2822

Abstract

Abstract : Background: Granulomatosis with polyangiitis (GPA) is a systemic inflammatory condition; however, patients with GPA rarely experience endocardial valve lesions. Methods: We report a GPA case with tricuspid valve destruction together with a systematic review to highlight the characteristics of all previously reported GPA cases with valvular involvement. Results: Among 36 cases included, the aortic valve was involved in 15 (41.7%) cases while the mitral valve was involved in 9 (25%) subjects. Combined lesion of both aortic and mitral valves was reported in 9 (25%) patients. Conclusion: We recommend routine echocardiography examination to rule out any cardiac valve lesion once GPA is suspected.