Long-term systemic lupus erythematosus disease control after allogeneic bone marrow transplantation. (June 2017)

• Record Type: Journal Article
• Authors: Gladstone, D E; Petri, M; Bolaños-Meade, J; Dezern, A E; Jones, R J; Fine, D; Brodsky, R A
• Is Part Of: Lupus. Volume 26:Number 7(2017)
• Page Start: 773
• Page End: 776
• Publication Date: 2017-06
• Subjects: Systemic lupus erythematosus -- alloBMT; Systemic lupus erythematosus -- Periodicals; 616.772005
• DOI: 10.1177/0961203316669242
• Languages: English
• ISSNs: 0961-2033

Abstract

Systemic lupus erythematosus (SLE), a disorder of the immune system, is potentially curable by allogeneic bone marrow transplantation (alloBMT). Until recently, alloBMT was limited by donor availability and toxicity. Reduced intensity conditioning (RIC) combined with post-transplantation cyclophosphamide (PTCy) has improved the availability and safety of alloBMT permitting its exploration in severe-refractory autoimmune illnesses. We report the six-year follow-up of a young female whose refractory SLE-associated nephrosis resolved after RIC alloBMT with PTCy.