A polymorphism within the psoriasis susceptibility 1 candidate 1 (PSORS1C1) gene is not linked to HLA-B*58:01 in an Australian cohort. Issue 3 (June 2016)

• Record Type: Journal Article
• Authors: Vidal, C.; Li, J.; Fulton, R.; Fernando, S.L.
• Is Part Of: Drug metabolism and pharmacokinetics. Volume 31:Issue 3(2016)
• Page Start: 252
• Page End: 255
• Publication Date: 2016-06
• Subjects: Linkage disequilibrium -- Polymorphism -- HLA -- Severe adverse drug reactions -- Abacavir -- Allopurinol -- Carbamazepine; Drugs -- Metabolism -- Periodicals; Pharmacokinetics -- Periodicals; 615.7
• DOI: 10.1016/j.dmpk.2015.08.007
• Languages: English
• ISSNs: 1347-4367

Abstract

Abstract: Association exists between HLA-B*58:01 allele and allopurinol Stevens-Johnson syndrome (SJS), especially those of an Asian heritage but associations have been also described in Caucasian populations. This creates the need to develop a rapid, robust and inexpensive assay for pre-screening of HLA-B*58:01. A polymorphism within PSORS1C1 gene was recently found in linkage disequilibrium (LD) with HLA-B*58:01 allele in the Japanese population. The aim of this study is to confirm whether this polymorphism can be used as a surrogate biomarker to identify carriers for HLA-B*58:01. No linkage was found between the two in the Australian cohort.