Three-Dimensional Cell Cultures in Drug Discovery and Development. (June 2017)

• Record Type: Journal Article
• Authors: Fang, Ye; Eglen, Richard M.
• Other Names: Eglen Richard M. guest-editor.; Klein Jean-Louis guest-editor.
• Is Part Of: SLAS discovery. Volume 22:Number 5(2017)
• Page Start: 456
• Page End: 472
• Publication Date: 2017-06
• Subjects: 3D cell culture -- 3D bioprinting -- disease models -- efficacy -- organoids -- organs-on-chips -- safety -- screening -- multicellular spheroid -- toxicity; Drugs -- Analysis -- Periodicals; Drugs -- Testing -- Periodicals; Biomolecules -- Analysis -- Periodicals; Biomolecules -- Analysis; Drugs -- Analysis; Drugs -- Testing; Drug Evaluation, Preclinical; Molecular Biology -- methods; Periodicals; Periodicals; 615.1
• DOI: 10.1177/1087057117696795
• Languages: English
• ISSNs: 2472-5552

Abstract

The past decades have witnessed significant efforts toward the development of three-dimensional (3D) cell cultures as systems that better mimic in vivo physiology. Today, 3D cell cultures are emerging, not only as a new tool in early drug discovery but also as potential therapeutics to treat disease. In this review, we assess leading 3D cell culture technologies and their impact on drug discovery, including spheroids, organoids, scaffolds, hydrogels, organs-on-chips, and 3D bioprinting. We also discuss the implementation of these technologies in compound identification, screening, and development, ranging from disease modeling to assessment of efficacy and safety profiles.