KIF13B-NRG1 Gene Fusion and KRAS Amplification in a Case of Natural Progression of Lung Cancer. (May 2017)

• Record Type: Journal Article
• Authors: Xia, Daniel; Le, Long Phi; Iafrate, Anthony John; Lennerz, Jochen
• Is Part Of: International journal of surgical pathology. Volume 25:Number 3(2017)
• Page Start: 238
• Page End: 240
• Publication Date: 2017-05
• Subjects: lung cancer -- molecular pathology -- NRG1 fusion -- KRAS amplification; Pathology, Surgical -- Periodicals; 617.07
• DOI: 10.1177/1066896917693092
• Languages: English
• ISSNs: 1066-8969

Abstract

An 85-year-old woman with a history of several primary lung cancers presented with liver metastases. The primary lung cancers were all managed surgically and the patient did not receive adjuvant or neoadjuvant therapy prior to presenting with metastases. Comparison of molecular testing results from the most recent primary and the liver metastases demonstrated ( a ) a clonal relationship between the 2 cancers and ( 2 ) the presence of a KIF13B-NRG1 fusion and KRAS amplification unique to the metastases. When integrated, the molecular surgical pathology findings in this case illustrate the extent of "oncogenic drive" in preterminal lung cancer.