Metachronous Uterine Endometrioid Adenocarcinoma and Peritoneal Mesothelioma in Lynch Syndrome: A Case Report. (May 2017)

• Record Type: Journal Article
• Authors: Lu, Yuxin; Milchgrub, Sara; Khatri, Gaurav; Gopal, Purva
• Is Part Of: International journal of surgical pathology. Volume 25:Number 3(2017)
• Page Start: 253
• Page End: 257
• Publication Date: 2017-05
• Subjects: Lynch syndrome -- endometrioid adenocarcinoma -- peritoneal mesothelioma; Pathology, Surgical -- Periodicals; 617.07
• DOI: 10.1177/1066896916680745
• Languages: English
• ISSNs: 1066-8969

Abstract

Lynch syndrome is a hereditary disease with germline mutation in a DNA mismatch repair gene, most often presenting with colorectal and/or endometrial carcinomas; however, the spectrum of Lynch syndrome–associated tumors is expanding. In this article, we report a case of a primary peritoneal epithelioid mesothelioma that developed in a Lynch syndrome patient 10 months after diagnosis of uterine endometrioid adenocarcinoma. To our knowledge, this is the first reported case of a Lynch syndrome patient with metachronous uterine endometrioid adenocarcinoma and primary peritoneal mesothelioma.