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Synthesis of fluazolate via the application of regioselective [3+2] cyclocondensation and nucleophilic substitution-cyclization strategies. Issue 39 (29th September 2016)
Record Type:
Journal Article
Title:
Synthesis of fluazolate via the application of regioselective [3+2] cyclocondensation and nucleophilic substitution-cyclization strategies. Issue 39 (29th September 2016)
Main Title:
Synthesis of fluazolate via the application of regioselective [3+2] cyclocondensation and nucleophilic substitution-cyclization strategies
Abstract: Starting from commercially available 2-chloro-4-fluorobenzoic acid4, synthesis of fluazolate was achieved in up to 30% overall yield via the key procedure of either regioselective [3+2] cyclocondensation of trifluoromethyl-α, β-ynone2 with hydrazine hydrate or nucleophilic substitution-cyclization of trifluoromethyl-α, β-dibromoenone10 with hydrazine hydrate. Graphical abstract: