Radical arylation of tyrosine residues in peptides. Issue 48 (1st December 2016) - Fehler, Stefanie K.
Abstract: The radical arylation of the phenolic side chain of tyrosine in peptides was investigated. Aryl radicals were generated from aryldiazonium salts using titanium(III) chloride as stoichiometric reductant. Due to the high selectivity with which 3-aryltyrosine derivatives were formed, this reaction type represents a new strategy for the direct functionalization of peptides. Graphical abstract: