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Asymmetric synthesis of pyrano[2, 3-c]pyrazoles via a cascade reaction between Morita–Baylis–Hillman acetates of nitroalkenes and pyrazolones. Issue 27 (7th July 2016)
Record Type:
Journal Article
Title:
Asymmetric synthesis of pyrano[2, 3-c]pyrazoles via a cascade reaction between Morita–Baylis–Hillman acetates of nitroalkenes and pyrazolones. Issue 27 (7th July 2016)
Main Title:
Asymmetric synthesis of pyrano[2, 3-c]pyrazoles via a cascade reaction between Morita–Baylis–Hillman acetates of nitroalkenes and pyrazolones
Abstract: The first organocatalytic enantioselective cascade reaction of Morita–Baylis–Hillman acetates of nitroalkenes with pyrazolones has been developed. With 20 mol % of chiral tertiary-amine squaramide, 1, 4, 5, 6-tetrahydropyrano[2, 3-c]pyrazoles were afforded in moderate yields (up to 71%) with excellent stereoselectivities (up to>99:1 dr and up to 98% ee). Graphical abstract: