Enantioselective synthesis of BE ring analogues of methyllycaconitine. Issue 3 (21st January 2016)
- Record Type:
- Journal Article
- Title:
- Enantioselective synthesis of BE ring analogues of methyllycaconitine. Issue 3 (21st January 2016)
- Main Title:
- Enantioselective synthesis of BE ring analogues of methyllycaconitine
- Authors:
- Dickson, Emma
Pilkington, Lisa I.
Brimble, Margaret A.
Barker, David - Abstract:
- Abstract: The enantioselective synthesis of decahydroquinolines mimicking the BE rings of methyllycaconitine (MLA) is reported. The analogues were synthesised via a one-pot cyclisation using ethyl α-(bromomethyl)acrylate, ( R )-1-phenylethanamine and cyclohexanone to form chiral octahydroquinolines which can be selectively hydrogenated to form the 3-substituted-decahydroquinolines with the same stereochemistry found in MLA. The amine and ketone components in the one-pot reaction can also be altered to provide access to structurally related heterocycles. Graphical abstract:
- Is Part Of:
- Tetrahedron. Volume 72:Issue 3(2016)
- Journal:
- Tetrahedron
- Issue:
- Volume 72:Issue 3(2016)
- Issue Display:
- Volume 72, Issue 3 (2016)
- Year:
- 2016
- Volume:
- 72
- Issue:
- 3
- Issue Sort Value:
- 2016-0072-0003-0000
- Page Start:
- 400
- Page End:
- 414
- Publication Date:
- 2016-01-21
- Subjects:
- Multi-component reaction -- Quinolones -- Methyllycaconitine -- Enantioselective synthesis
Chemistry, Organic -- Periodicals
547.005 - Journal URLs:
- http://www.elsevier.com/journals ↗
- DOI:
- 10.1016/j.tet.2015.11.057 ↗
- Languages:
- English
- ISSNs:
- 0040-4020
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 8796.850000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 7514.xml