Resolution of Q Fever–Associated Cryoglobulinemia With Anti-CD20 Monoclonal Antibody Treatment. (January 2017)

• Record Type: Journal Article
• Authors: Hawkins, Kellie L.; Janoff, Edward N.; Janson, Robert W.
• Is Part Of: Journal of investigative medicine high impact case reports. Volume 5:Number 1(2017)
• Publication Date: 2017-01
• Subjects: Q fever -- cryoglobulinemia -- endocarditis -- rituximab; Internal medicine -- Periodicals; Medical care -- Periodicals; 616.005
• DOI: 10.1177/2324709616686612
• Languages: English
• ISSNs: 2324-7096

Abstract

Immunologic phenomena can complicate chronic infections with Coxiella burnetii (Q fever), including immune complex deposition causing vasculitis, neuropathy, and glomerulonephritis. We describe the case of a man with Q fever endocarditis, mixed cryoglobulinemia, and life-threatening vasculitis driven by immune complex deposition who was successfully treated with B cell depleting therapy (rituximab).