In a two-year double-blind randomized controlled multicenter study, chondroitin sulfate was significantly superior to celecoxib at reducing cartilage loss with similar efficacy at reducing disease symptoms in knee osteoarthritis patients. (April 2016) - Pelletier, J.; Raynauld, J.; Beaulieu, A.; Bessette, L.; Morin, F.; Fernandes, A.; Abram, F.; Dorais, M.; Martel-Pelletier, J.