Carbon Dots‐Cluster‐DOX Nanocomposites Fabricated by a Co‐Self‐Assembly Strategy for Tumor‐Targeted Bioimaging and Therapy. (7th August 2018)

• Record Type: Journal Article
• Authors: Deng, Tao; Zhang, Rong; Wang, Jie; Song, Xiaoxiao; Bao, Fangjian; Gu, Yueqing; Deng, Dawei
• Is Part Of: Particle and particle systems characterization. Volume 35:Number 9(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-08-07
• Subjects: bioimaging and tumor therapy -- cetylpyridinium chloride -- co‐self‐assembly -- doxorubicin -- oil‐soluble carbon dots; Particles -- Periodicals; 620.43
• DOI: 10.1002/ppsc.201800190
• Languages: English
• ISSNs: 0934-0866

Abstract

Abstract: Carbon‐based nanomaterials could afford versatile potential applications in biomedical optical imaging and as nanoparticle drug carriers, owing to their promising optical and biocompatible capabilities. In this paper, it is first found that amphipathic cetylpyridinium chloride (CPC)‐stabilized oil‐soluble carbon dots (CDs) could self‐assemble into hydrophilic CDs clusters with hydrophobic core under ultrasound, in which CPC acts as carbon source, stabilizer, and phase transfer agent. Next, the size‐control (for size‐dependent passive tumor targeting) and doxorubicin (DOX) uploading of aqueous CDs clusters, and subsequent surface charge modification via overcoating with cRGD‐ and octylamine‐modified polyacrylic acid (cRGD‐PAA‐OA) (reversing their surface charges into negative and introducing active tumor‐targeting ability) are explored systematically. Based on this sequential administration mode, CDs‐cluster‐DOX/cRGD‐PAA‐OA nanocomposites exhibit selective human malignant glioma cell line (U87MG) tumor targeting. In in vitro drug release experiments, the nanocomposites could release DOX timely. Owning to the dual tumor targeting effects and seasonable drug release, CDs‐cluster‐DOX/cRGD‐PAA‐OA show remarkably tumor targetability and enhanced antitumor efficacy (and reduced adverse reaction), comparing to free DOX in animal models. These results indicate that fabricating nanocomposite via co‐self‐assembly strategy is efficient toward drug delivery system for tumor‐targeting theranostic. Abstract : Constructing multifunctional drug delivery nanocomposites (carbon dots‐cluster‐doxorubicin/cRGD‐polyacrylic acid‐octylamine) via co‐self‐assembly strategy for tumor‐targeted bioimaging and therapy is reported.